The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones

Article Abstract:

The role of the RING finger protein Rnf6 during neuronal development and detected high Rnf6 protein levels in developing axonal projections of motor and DRG neurons during mouse embryogenesis as well as cultured hippocampal neuron is investigated. The result assigns a specific role for Rnf6 in the control of cellular LIM kinase 1 concentrations and indicates a new function for the ubiquitin/proteasome system in regulating local growth con actin dynamics.

Axonal transport, Ubiquitin-proteasome system

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The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans

Article Abstract:

The AMP:ATP ratio, a measure of energy levels increases with age in Caenorhabditis elegans and can be used to predict life expectancy. The C. elegans AMP-activated protein kinase alpha subunit AAK-2 is activated by AMP and functions to extend lifespan.

Genetic aspects, Caenorhabditis elegans, Genetic research

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