Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT

Article Abstract:

A study shows that disruption of Hsp90 by geldanamycin promotes efficient ubiquitination and proteasome-mediated degradation of hTERT and yeast two-hybrid method is used to identify a novel RING finger gene (MKRN1) encoding an E3 ligase that mediates ubiquitination of hTERT. The results of the study suggest that MKRN1 plays an important role in modulating telomere length homeostasis through a dynamic balance involving hTERT protein stability.

United States, Proteolysis, Ubiquitin, Homeostasis

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SV40 T antigen interacts with Nbs1 to disrupt DNA replication control

Article Abstract:

The simian virus 40 (SV40) oncoprotein, large T antigen (T), interacts with Nbs1, and T-containing cells experience chromosomal hyperreplication in a manner dependent on T/Nbs1 complex formation. Nbs1 suppresses rereplication of cellular DNA and SV40 origin-containing replicons, and T targets Nbs1, thereby enhancing the yield of new SV40 genomes during viral DNA replication.

Genetic aspects, Mammals

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Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress

Article Abstract:

A study describes the role of Mcm2-7 in licensing dormant origins and their usage in a physiological context when checkpoint responses remain intact.

Mitosis, DNA binding proteins, RNA interference

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