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(CA/GT)(sub.n) microsatellites affect homologous recombination during yeast meiosis

Article Abstract:

(CA/GT)(sub.n) microsatellites have an effect on yeast meiosis homologous recombination. Behavior of a region of the Saccharomyces cerevisiae genome containing a 39-CA/GT dinucleotide repeat sequence has been studied. Meiotic instability of the microsatellite was very high in all spores with recombinant and parental chromosomes, a surprise.

Author: Gendrel, Christiane-Gabrielle, Boulet, Annick, Dutreis, Marie
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
Genomes, Genetic recombination, Saccharomyces, Meiosis

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The set1(Delta) mutation unveils a novel signaling pathway related by the Rad53-dependent hyperphosphorylation of replication protein A that leads to transcriptional activation of repair genes

Article Abstract:

Constitutive MEC1/TEL1-independent hyperphosphorylation of Rfa2p is brought on by inactivation of Set1p in a process requiring Rad53p. A pathway that shows why Set1p inactivation raises repair capabilities of the cell when checkpoints fail has been documented. The response is unlike the MEc1-dependent DNA damage induction pathway.

Author: Lucchini, Giovanna, Longhese, Maria Pia, Schramke, Vera, Neecke, Holger, Brevet, Vanessa, Corda, Yves, Gilson, Eric, Geli, Vincent
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2001
Telomeres, Gene expression, Phosphorylation

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NHEJ regulation by mating type is exercised through a novel protein, Lif2p, essential to the Ligase IV pathway

Article Abstract:

Nonhomologous end-joining (NHEJ) regulation by mating type in Saccharomyces cerevisiae has been found to work, at least in part, through a novel protein required for the Ligase IV pathway, Lif2p. DNA double-strand break (DSB) repair by NHEJ has been studied.

Author: Frank-Vaillant, Marie, Marcand, Stephane
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2001

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Subjects list: Research, France, Physiological aspects, Genetic aspects, Cytochemistry, Yeast, Yeast (Food product), Statistical Data Included, DNA repair
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