The signal transducer encoded by ampG is essential for induction of chromosomal AmpC beta-lactamase in Escherichia coli by beta-lactam antibiotics and 'unspecific' inducers

Article Abstract:

The genes for AmpG beta-lactamase from Citrobacter freundii were introduced into Escherichia coli and induced to mutate into four different mutations. These four mutants were unable to exhibit limited capabilities to produce beta-lactamase in response to beta-lactam antibiotics. Nucleotide sequencing of the mutant genes revealed substitutions of aspartate for glycine, or the presence of the wild-type gene with limited expression. These mutations reverted to the wild type after spontaneous back-mutation.

Antibiotics

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Antibacterials that are used as growth promoters in animal husbandry can affect the release of Shiga-toxin-2-converting bacteriophages and Shiga toxin 2 from Escherichia coli strains

Article Abstract:

Ability of growth-promoting antibiotics to bring on Shiga-toxin (Stx)-converting bacteriophages from Stx-producing Escherichia coli (STEC) strains in farm animals has been studied. Tylosin and monensin cut down on phage induction. Production of Stx increased /decreased in proportion to free phages.

Germany, Usage, Prevention, Physiological aspects, Drug therapy, Veterinary drugs, Antibacterial agents, Escherichia coli, Bacteriophages, Microbial toxins, Animal culture, Animal husbandry

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The signal transducer (BlaRI) and the repressor (BlaI) of the Staphylococcus aureus beta-lactamase operon are inducible

Article Abstract:

Results indicate that the promoters for both the signal transducer/repressor blaRI/blaI as well as their mRNA are inducible. Data point out that the promoters also synthesize chloramphenicol acetyltransferase.

United Kingdom, Statistical Data Included, Analysis, Staphylococcus aureus, Genetic regulation, Promoters (Genetics), Genetic transcription, Transcription (Genetics)

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