Role of the rasGAP-associated docking protein p62(super.dok) in negative regulation of B cell receptor-mediated signaling

Article Abstract:

When cross-linking of B-cell receptor (BCR) or BCR with Fc(gamma)RIIB, the rasGAP-associated protein p62(super.dok) is prominently tyrosine phosphorylated Lyn-dependently. When BCR cross-linking takes place, p62dok suppresses MAP kinase and is indispensable for Fc(gamma)RIIB-mediated negative regulation of cell proliferation. A downstream target of many protein tyrosine kinases (PTKs), p62(super.dok), seems to act negatively relative to various signaling events.

Autoimmune diseases, Cancer, Protein crosslinking, B cells, Cancer genetics

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The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse

Article Abstract:

FoxH1 (FAST), a transcription factor, has been found to mediate Nodal signaling in anterior-posterior (A-P) patterning and node formation in mice. Mutant mice lacking the transcription factor were generated and characterized. They died early in embryonic development and showed various patterning defects explained by absence of Nodal signaling. Nodal is a factor related to transforming growth factor-beta (TGF-beta) and a potent signaling molecule necessary for specification of the A-P axis, formation of the primitive streak, and left-right pat terning.

Growth factors, Embryology, Experimental, Embryological research, Gastrulation

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Mutant mice with scrambled brains: understanding the signaling pathways that control cell positioning in the CNS

Article Abstract:

Signaling pathways that control cell positioning in the central nervous system (CNS) are discussed relative to mutant mice and cell positioning in this review article. Cell migrations must take place in an organized fashion in the mammal to put together the extremely ordered array of neurons and projections needed for function. The reeler (ital) phenotype posed some questions, some of which are now answered but new questions have arisen related to mechanisms by which the large extracelluar protein send signals to migrating neurons. Reln, a secreted protein, and Dab1 bind lipoprotein receptors, the role of which in the Reln signaling pathway is of interest. The Reln gene is conserved in various vertebrate species.

Carrier proteins, Transport proteins, Central nervous system, Developmental biology, Neurons, Cell receptors, Mammals, Cell migration

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