The winged helix transcription factor Foxc1a is essential for somitogenesis in zebrafish

Article Abstract:

The winged helix transcription factor Foxc1a has been found to be necessary for zebrafish somitogenesis. Studies have shown zebrafish foxc1a and foxc1b to be homologs of the mouse forkhead gene, Foxc1. The study used a recently established targeted gene morpholino 'knockdown' technology. Gocv1a was needed for formation of the most anterior somites. The requirement for most other genes shows up later, for posterior somites.

United States, Statistical Data Included, Genetic transcription, Transcription (Genetics), Cytochemistry, Antisense DNA, Somites (Embryology)

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Control of her1 expression during zebrafish somitogenesis by a Delta-dependent oscillator and an independent wave-front activity

Article Abstract:

Zebrafish somitogenesis and control of her1 expression by an independent wave-front activity and a Delta-dependent oscillator are discussed. The zebrafish gene after eight (aei) needed for somitogenesis and neurogenesis encodes the Notch ligand Delta D. The undisturbed sequence of formation, refinement, and fading of her1 stripes in the presomitic mesoderm (PSM) is under dontrol of two activities, which are separate.

Germany, Genetic regulation, Cytogenetics

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Anterior-posterior differences in vertebrate segments: Specification of trunk and tail somites in the zebrafish blastula

Article Abstract:

Study is presented to address the question as to how the embryo allocates the cells remaining to make the most posterior somites at the end of somitogenesis. It is shown that cells are specified to give rise to anterior trunk, posterior trunk and tail somites and that this cell fate division occurs early in zebrafish development, prior to grastrulation, in response to nodal, fgf and bmp signaling.

Science & research, Connecticut, Analysis, Chromosome mapping, Animal embryology

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