The yeast SlS1 protein, a DnaJ homolog, is required for the initiation of translation

Article Abstract:

The dissociation of several protein complexes is mediated by the bacterial DnaJ protein, which is analogous to the heat shock protein encoded by S. Cerevisiae SIS1 gene. During the initiation of translation, SIS1 gene interposes the dissociation of specific protein complex of the translation system, and initiates the translation process. An analysis of sucrose gradients for SIS1 proteins illustrates the association of a large fraction of SIS1 with 40S ribosomal subunits and smaller polysomes.

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UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues

Article Abstract:

The unc-40 component of the netrin UNC-6 receptor mechanism which encodes a nematode homolog of the Deleted in Colorectal Cancer cell adhesion molecules and neogenin. Cellular responses to the signals of UNC-6 is mediated by UNC-40 during axonal migrations. Furthermore, disruptions in the migration of axons or the repulsive responses of neurons to UNC-6 sources are altered by mutations in unc-40 and, therefore, demonstrating its vital role in axiogenesis.

Physiological aspects, Genetic aspects, Promoters (Genetics), Axons, Cell migration

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Ancient ciphers: translation in archaea

Article Abstract:

The archaean translation apparatus makes use of combinations of bacterial and rudimentary eucaryl features. Proper understanding of bacterial and eucaryal translation entails familiarizing on how these features interface with archaea. Archaeal genome sequences are useful areas in biochemical investigations pre-rRNA processing, translation initiation and ribosomal subunit formation.

Ribosomal RNA

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