Toxoplasma gondii sequesters lysosomes from mammalian hosts in the vacuolar space

Article Abstract:

The intracellular compartment harboring Toxoplasma gondii satisfies the parasite's nutritional needs for rapid growth in mammalian cells. It is demonstrated that the parasitophorous vacuole (PV) of T. gondii accumulates material coming from the host mammalian cell via the exploitation of the host endo-lysomal system, and the parasite actively recruits host microtubules, resulting in selective attraction of endo-lysosomes to the PV.

Science & research, Research, Genetic aspects, Parasites, Genetic research, Toxoplasma

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Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3)

Article Abstract:

Research shows that six different mutations in the hMunc13-4, a member of the Munc13 family of proteins, indicate that the gene is not required for granule polarization and membrane docking. However, it is essential for the secretion of cytotoxic granules during exocytosis. Together, results implicate HMunc13-4 mutations in the development of FHL3.

Israel, France, Influence, Gene mutations, Gene mutation, Lymphocytes

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Plasma membrane repair is mediated by Ca(sup)2+ -regulated exocytosis of lysosomes

Article Abstract:

Research demonstrates that calcium-regulated exocytosis of lysosomes repairs plasma membrane disruptions and intracellular calcium concentration increase initiates fusion of lysosomes with the plasma membrane. Data show that resealing of wounded primary skin fibroblasts are repaired by lysosomal exocytosis.

United States, Plasma membranes, Fibroblasts, Regeneration (Biology)

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