Trypanosome invasion of mammalian cells requires activation of the TGFbeta signalling pathway

Article Abstract:

Trypanosoma cruzi clings to epithelial cells without signaling transforming growth factor beta (TGF beta) receptor I or II and the adherent parasites cannot enter and replicate inside the mutant cells as they can do in parent cell. Intrusion of the mutants is recovered by transfection with the TGF beta receptor genes, as are biological responses to TGF beta. The same kind of rescue of both TGF beta antiproliferative response and T. cruzi intrusion was shown in a hybrid of TGF beta-resistant bladder and colon carcinoma cells.

Transforming growth factors, Trypanosoma cruzi

---

The molecular biography of the cell

Article Abstract:

The development of an adult organism from a single fertilized egg, a stage from inner cell mass to fully differentiated structure is discussed. The challenge of developmental biology lies in defining the influences and factors that contribute to the final destination are explored.

Science & research, Developmental biology, Embryology, Eggs (Biology), Egg (Biology)

---

Similar abstracts:

• Abstracts: Neural induction in Xenopus requires inhibition of Wnt-?-catenin signaling
• Abstracts: The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1
• Abstracts: Gene expression in the cos region of the Streptomyces temperate actinophage phi-C31. Expression of two alternative sigma factors of Synechococcus sp. strain PCC 7002 is modulated by carbon and nitrogen stress
• Abstracts: Fur regulates the expression of iron-stress genes in the cyanobacterium Synechococcus sp. strain PCC 7942. somA, a novel gene that encodes a major outer-membrane protein of Synechococcus sp. PCC 7942
• Abstracts: Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression. Linker histone H1 regulates specific gene expression but not global transcription in vivo

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.