Transcriptional regulation by extracellular signals: mechanisms and specificity

Article Abstract:

Extracellular signals promote or suppress transcription by targeting transcription factors in the nucleus, binding to DNA and interacting with the basal transcription system. Phosphorylation of transcription factors is a common mechanism of regulation by extracellular signals. Some regulatory pathways involve transport of signaling molecules into the nucleus while others involve the transport of activated transcription factors to the cytoplasm or membrane. The functioning of signaling molecules as a promoter or suppressor of transcription depends on the combinatorial interaction between different signaling pathways.

Cellular signal transduction, Genetic regulation, Genetic transcription, Transcription (Genetics), Phosphorylation

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Activation of SRF-regulated chromosomal templates by Rho-family GTPases requires a signal that also induces H4 hyperacetylation

Article Abstract:

Research was conducted to test whether the activation of Rho-controlled signal pathways is enough to activate chromosomal c-fos genes. DNA was manipulated by standard techniques while reporter cell lines were determined following the transfection of NIH3T3 cells by calcium phosphate precipitation. Results indicated that the activation of chromosomally located serum response factor-controlled reported genes was dependent on two kinds of signals.

Chromosomes, Genetic research, Guanosine triphosphatase, Rho(D) immune globulin

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Signal-regulated activation of serum response factor is mediated by changes in actin dynamics

Article Abstract:

LIM kinase-1 was found to be a potent activator of serum response factor (SRF). With the use of a functional screen, it was shown that LIM-kinase-1's ability to activate SRF relies on its ability to regulate actin treadmilling, a cycle that acts as a convergence point for both serum- and LIM kinase 1-induced signaling to SRF. The importance of actin dynamics regulation in the serum induction of a subset of SRF target genes was also established.

Physiological aspects, Muscles, Actin, Heredity

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