Tumor induction and tissue atrophy in mice lacking E2F-1

Article Abstract:

The inactivation of E2F-1 genes by homologous recombination produced testicular atrophy, exocrine gland dysplasia and tumorigenesis in 15-month old mice. The development of reproductive tract sarcomas, lung tumors and lymphomas in E2F-1-deficient mice indicate the tumor-suppressive functions of E2F-1. E2F-1 normally suppress genes that activate genetic inhibitors of metastasis. The exocrine cells of E2F-1-deficient mice exhibit large and doubled nuclei due to an uncontrolled DNA replication without cell division. The overexpression of E2F-1 stimulate cell proliferation and oncogenetic activity.

Genetic transcription, Transcription (Genetics), Carcinogenesis, Oncogenes

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Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor

Article Abstract:

Research has been conducted on NF1 tumor suppressor mutations. The authors demonstrate that encoded protein neurofibromin is dynamically regulated by the ubiquitin-proteasome pathway.

United States, Science & research, Research, Analysis, Proteolysis, Genetic research, Tumour suppressor genes

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