CLASPs are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts

Article Abstract:

Two CLIP-associated proteins (CLASPs) have been isolated. CLIP-170 and CLIP-115 are cytoplasmic linker proteins that associate specifically with the ends of growing microtubules and may function as anti-catastrophe factors. CLASPs are homologous to the Drosophila Orbit/Mast microtubule-associated protein and appear to be involved in the local regulation of microtubule dynamics, responding to positional cues.

Netherlands, Statistical Data Included, Cytochemistry, Fibroblasts, Cytoplasm

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Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics

Article Abstract:

Research has been conducted on microtubule-associated protein CLASP1. The authors demonstrate that this protein localizes near the plus end of the growing spindle microtubules and is a kinetochore region component, and suggest that CLASP1 is important for attached microtubules to display normal dynamic behavior.

United States, Portugal, Scotland, Analysis, Cell research, Cytological research, Kinetochores

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The microtubule plus-end tracking protein CLIP-170 associates with the spermatid manchette and is essential for spermatogenesis

Article Abstract:

The function of mouse cytoplasmic linker protein of 170 kDa (CLIP-170) is examined. It is found that Clip-170 is able to act both as a (+)TIP and as a structural protein and is also important for normal spermatogenesis.

Science & research, Mice, House mouse, Cytoplasmic filaments, Spermatogenesis in animals, Animal spermatogenesis

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