vhnf1, the MODY5 and familial GCKD-associated gene, regulates regional specification of the zebrafish gut, pronephros, and hindbrain

Article Abstract:

Research has been conducted on the homeobox gene vHnf1 mutations associated with the maturity-onset diabetes of the young, type V and glomerulocystic kidney disease. The isolation of the zebrafish vhnf1 mutant alleles has been carried out and the results indicate that the mutants' phenotypes include kidney cyst formation and pancreas and liver underdevelopment, demonstrating that these abnormalities arise from the patterning defects during development.

Analysis, Abnormalities, Physiological aspects, Diabetes, Diabetes mellitus, Kidneys, Phenotype, Phenotypes, Kidney, Genetic research

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Gata5 is required for the development of the heart and endoderm in zebrafish

Article Abstract:

The zinc finger transcription factor Gata5 encoded by the faust locus has been shown to be necessary for the development of the endoderm and heart in zebrafish. Gata5 regulates expression of the early myocardial gene nkx2.5. Mechanisms regulating vertebrate heart and endoderm development are now of much interest. Evidence from gain-of-function and loss-of-function experiments is presented.

United Kingdom, Liver, Physiological regulation, Gene expression, Embryology, Experimental, Embryological research, Biological control systems, Morphogenesis

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Zebrafish mutations and functional analysis of the vertebrate genome

Article Abstract:

Recent advances in genomic resources that will add to cloning mutated zerbrafish genes by positional cloning, insertional mutagenesis, the candidate gene approach are reviewed. Facile genetics of zebrafish allow for rapid isolation of mutations. Phenotypic analysis can show gene functions difficult to find in other systems.

Vertebrates

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