Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death

Article Abstract:

Signaling pathways regulating survival of cells are in the early stages of being defined. Components of survival signal transduction are of interest. An important family of cytoplasmic proteins seems to be capable of negatively regulating apoptotic pathways and can induce expression of genes that help cells to survive. The family has been given the name tumor necrosis factor (TNF) receptor-associated factors (TRAFs) because of ability to bind to TNFRII. This family of adapter proteins regulates death as well as life.

Observations, Proteins, Cellular signal transduction, Genetic regulation, Cell cycle, Cell receptors, Tumor necrosis factor, Cell physiology, Cytoplasm

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Proteases to die for

Article Abstract:

Cysteine proteases with aspartate-specificity (caspases) play a critical role in apoptosis or cell death. Recent findings about the way the rest of the process affects the caspases and the actual process in which caspases affect cell death are reviewed. The genetic process of programmed cell-death is explained.

Proteases

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