Network analyses of Y-chromosomal types in Europe, Northern Africa, and Western Asia reveal specific patterns of geographic distribution

Article Abstract:

Common descent followed by molecular radiation accounts for most of the phenetic relationships among haplotypes in four Y-linked dinucleotide microsatellites among 908 men from Europe, northern Africa, and western Asia. Six large networks and two small ones emerged. The complete diversity within a sample can be partitioned using this technique. A low level of homoplasy is found among dinucleotide microsatellite haplotypes. Populations are highly structured in terms of Y-chromosomal network frequencies.

Europe, Middle East, Northern Africa, Demographic aspects, Human population genetics, Human geography, Y chromosome

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Identification of a mutation cluster in mevalonate kinase deficiency, including a new mutation in a patient of Mennonite ancestry

Article Abstract:

A new mutation in a patient of Mennonite ancestry is discussed with information about identification of a mevalonate kinase (MKase) deficiency (MKD) mutation cluster within amino acids 240-270 of the mature MKase polypeptide. MKD is a rare autosomal recessive disorder in the pathway for nonsterol isoprenoid and cholesterol biosynthesis and the new information should make better accuracy in identification of carriers possible.

United States, Germany, France, Czech Republic, Statistical Data Included, Usage, Physiological aspects, Gene mutations, Gene mutation, Genetic aspects, Chromosome mapping, Protein kinases, Genetic disorders, Cholesterol, Mennonites, Peroxisomes

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