Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry

Article Abstract:

Chemokine receptors are members of the larger family of G-protein-coupled seven-transmembrane-segment (7TMS) receptors that are known to have diverse roles in many biological processes. One chemokine receptor, CCR5, is known to serve as a coreceptor of HIV and SIV together with CD4. This receptor serves as a facilitator of viral entry into their target cells. It is shown that CCR5 is posttranslationally modified by O-linked glycosylation and by sulfation of its N-terminal tyrosines. Results suggest that this sulfation activity is a characteristic of many HIV and SIV coreceptors.

Cell receptors, Tyrosine

---

Viral latency in HIV disease

Article Abstract:

The cellular dynamics of HIV disease are intricate as infected cells with productive or latent genomes can live together without obvious signs or symptoms. Cells with latent genomes may stand for a small fraction of the sum of infected cells or may often have defective genomes. In such a case, they may create an insignificant pool for virus spread in vivo, at least in the case of a 'steady-state' analysis of late-stage disease. In the analysis of HIV, it is significant to comprehend the role that different populations of HIV-infected cells play in disease progression.

---

Epigenetic programming of developmental genome rearrangements in ciliates

Article Abstract:

Research has shown DNA metabolism to be affected by epigenetic modifications of genomic sequences. In one recent study, evidence was found of an epigenetic regulation of genetic rearrangements in ciliates, where sexual events are followed by the differentiation of two kinds of nuclei from the diploid zygotic nucleus within the same cytoplasm. The germ-line encodes for the rearrangement program.

Genetic aspects, Ciliata, Epigenesis, Ciliates

Similar abstracts:

• Abstracts: On-line visualization of the competitive behavior of antagonistic bacteria. Diversity and antagonistic potential of bacteria associated with bryophytes from nutrient-poor habitats of the Baltic Sea coast
• Abstracts: Degradation and mineralization of atrazine by a soil bacterial isolate. Secondary metabolites resulting from degradation of PR toxin by Penicillium roqueforti
• Abstracts: Organization of the canine major histocompatibility complex: current perspectives. Hereditary evaluation of multiple developmental abnormalities in the Havanese dog breed
• Abstracts: Comparative analysis of the vocalizations of hylorchilus wrens. Characteristics, use and possible functions of the perch songs and chatter calls of male Common Yellowthroats
• Abstracts: The initiation of the limb bud: growth factors, hox genes, and retinoids. Rethinking the proximodistal axis of the vertebrate limb in the molecular era

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.