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PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells

Article Abstract:

The expression of protease-activated receptors (PARs) is both required and sufficient to promote growth and invasion of breast carcinoma cells in a xenograft model. It is demonstrated that matrix metalloprotease in the stromal-tumor microenvironment can alter the behavior of cancer cells through PAR1 to promote cell migration and invasion.

Author: Boire, Adrienne, Covic, Lidija, Agarwal, Anika, Jacques, Suzanne, Sherifi, Sheida, Kuliopulos, Athan
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
Cancer cells, Matrix metalloproteinase inhibitors

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Vessels and nerves: Marching to the same tune

Article Abstract:

The patterning of the nervous system is achieved through coordinated action of a variety of repulsive or attractive neuronal guidance factors that direct the growth of growing axons to specific pathways. It is suggested that similar sets of factors also guide migration of endothelial cells.

Author: Weinstein, Brant M.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
Endothelium

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Vessels and nerves: Marching to the same tune

Article Abstract:

The patterning of the nervous system is achieved through coordinated action of a variety of repulsive or attractive neuronal guidance factors that direct the growth of growing axons to specific pathways. It is suggested that similar sets of factors also guide migration of endothelial cells.

Author: Weinstein, Brant M.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
Axons, Phytochrome

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Subjects list: Research, Cell migration
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