The InsP3 receptor: Its role in neuronal physiology and neurodegeneration

Article Abstract:

The InsP3 receptor is a ligand-gated channel that releases Ca(super 2+) from intracellular stores in a variety of cell types, including neurons. Genetic studies from vertebrate and invertebrate model systems suggest that coordinated rhythmic motor functions are most susceptible to changes in Ca(super 2+) release from the InsP3 receptor.

All Other Basic Inorganic Chemical Manufacturing, Calcium & Compounds, Genetic aspects, Vertebrates, Invertebrates, Calcium compounds, Homeostasis

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Nonsense-mediated RNA decay: A molecular system micromanaging individual gene and suppressing genomic noise

Article Abstract:

Nonsense-mediated RNA decay (NMD) is an evolutionary conservative system of RNA surveillance that detects and degrades RNA transcripts containing nonsense mutations. The results obtained show that in human cells, NMD regulates hundreds of physiological transcripts as well as those containing nonsense mutations.

Gene mutations, Gene mutation, RNA, Human cell culture

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