Waves of malarial var-iations

Article Abstract:

The Plasmodium parasite has the ability to vary the polypeptides it exports to infected erythrocytes so that reappearing variants in chronic malaria infections are always distinct from those of the parental parasite. This antigen variation is attributable to the activity of schizont-infected cell agglutination (SICA) antigens which can be found on the Plasmodium-infected erythrocyte surface. Together with the adhesin PfEMP1, which plays a key role in mediating binding to uninfected erythrocytes, SICA antigens seem to be the most promising targets for further research into antigenic variation.

Care and treatment, Vaccines, Malaria, Parasitism, Antigens, Plasmodium, Plasmodium (Protozoa)

---

Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes

Article Abstract:

Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) cloned from the Malayan camp parasite strain is an antigenically distinct malarial protein present on the surface of parasitized erythrocytes (PE). PE can bind to endothelial surfaces of blood vessels, which is responsible for some of the symptoms of malaria. PfEMP1 confers antigenic variation and is the receptor that binds to endothelium. PfEMP1 could be used in a malaria vaccine.

---

Targeted gene disruption shows that knobs enable malaria-infected red cells to cytoadhere under physiological shear stress

Article Abstract:

Researchers disrupted the gene encoding knob-associated histidine-rich protein (KAHRP) to show its importance in knob formation. The binding of knob transfectants to CD36 was reduced when done under flow conditions that mimic those of post-capillary venules. The findings indicate that knobs on P. falciparum-infected red cells play a key role in the binding of parasitized-erythrocytes to microvascular endothelium.

Proteins

Similar abstracts:

• Abstracts: Molecular variation of Adh and P6 genes in an African population of Drosophilamelanogaster and its relation to chromosomal inversions
• Abstracts: Targeted disruption of the p50 subunit of Nf-kappa-B leads to multifocal defects in immune responses. Solution structure of the C-terminal core domain of human TFIIB: similarity to cyclin A and interaction with TATA-binding protein
• Abstracts: Inhibition and facilitation of nucleic acid amplification. Viability and DNA maintenance in nonculturable spiral Campylobacter jejuni cells after long-term exposure to low temperatures
• Abstracts: Solution structure of the C-terminal core domain of human TFIIB: similarity to cyclin A and interaction with TATA-binding protein
• Abstracts: E-cadherin is the receptor for internalin, a surface protein required for entry of L. monocytogenes into epithelial cells

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.