Why do cancer cells metastasize into particular organs?

Article Abstract:

Studies have shown that the viability of cancer cells in metastatic colonies is due to the presence of growth stimulators that determine their survival in these ectopic sites. Tumor cells first lodge in the microvasculature of target organs or interact with host platelets, vascular endothelium and subendothelial basement membranes then degrade the extracellular matrix to release organ-specific factors that directs their subsequent migration. Immunological tolerance and autocrine and paracrine growth stimulators then determine metatastatic growth.

Cancer research, Growth, Cancer cells

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Local proteolytic activity in tumor cell invasion and metastasis

Article Abstract:

Mechanisms and functions of local proteolytic activity, especially on tumor cell invasion and metastasis are studied with main focus on the techniques for this investigation. Though various methods of detecting proteolytic activity reveal high concentrations of proteases in and around cancerous cells than in normal ones, improved methods are necessary to enable imaging and quantification to understand and design new drugs for tumor cell invasion.

Proteases

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Activation of the Nrf2-ARE signaling pathway: A promising strategy in cancer prevention

Article Abstract:

A key finding in the field of chemopreventive was discovered, that the induction of these enzymes is mediated by the cytoplasmic oxidative stress system (Nfr2-Keap1). Under basal conditions, Keap-1 anchors the Nrf2 transcription factor within the cytoplasm, targeting it for ubiquitination and proteasome degradation, thus repressing its ability to induce phase II genes.

Cancer prevention, Cytoplasm, Oxidative stress

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