Regulatory mechanisms for ras proteins

Article Abstract:

Negative and positive regulators effect the control of ras proto-oncogene protein (p21) expression. These include p120(super GAP), neurofibromatosis type 1 genes, exchange proteins, guanosine disphosphatase inhibitors, protein kinase C phosphorylation, post-translational modifications and transcriptional and translational mechanisms. These are essential for the optimal functioning of ras oncogenes in cell growth and differentiation.

Methods, Genetic regulation, Oncogenes

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Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

Article Abstract:

The Son of sevenless (Sos) protein in rat-1 fibroblasts acts as a specific guanine nucleotide exchange factor for Ras. Epidermal growth factor (EGF) treatment of cells promotes the formation of a complex of EGF receptor, Grb2, and Sos. These findings suggest that EGF-induced activation of nucleotide exchange on p21ras proceeds through the recruitment of cytosolic Sos to a complex with EGF receptor and Grb2 at the plasma membrane.

Epidermal growth factor, Epidermal growth factors, Proto-oncogenes

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Molecular mechanisms involved in Ras inactivation: The annexin A6-p120GAP complex

Article Abstract:

The involvement of annexin A6, as a [Ca.sup.2+]-sensor and targeting/scaffolding protein for GTPase-activating proteins (GAPs), such as p120GAP proteins, to promote Ras-GAP assembly and Ras inactivation is discussed. The results contribute to Ras signal specificity and describe the tumor suppressor activity of annexin A6 in some cell types.

United States, Science & research, Guanosine triphosphatase, GTPases

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