X-chromosome-wide profiling of MSL-1 distribution and dosage compensation in Drosophila

Article Abstract:

Dosage compensation is achieved in Drosophila by a twofold-up-regulation of the male X-linked genes and requires the association of the male-specific lethal complex (MSL) on the X chromosome. A report is presented on the MSL-1-binding profile along the male X chromosome in embryos and male salivary glands isolated from third instar larvae using chromatin immunoprecipitation (ChIP) coupled with DNA microarray (ChIP-chip).

Genetic aspects, Genetic regulation, Drosophila, Genetic research, X chromosome, DNA microarrays

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Guanosine triphosphate acts as a cofactor to promote assembly of initial P-element transposase-DNA synaptic complexes

Article Abstract:

Protein-DNA complexes formed during the initial stages of P-element transposition is visualized using atomic force microscopy (AFM). The results revealed that guanosine triphosphate (GTP) acts to promote assembly of the first detectable noncovalent precleavage synaptic complex.

Usage, DNA polymerases, Atomic force microscopy, GTP, Guanosine triphosphate

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