migA, a quorum-responsive gene of Pseudomonas aeruginosa, is highly expressed in the cystic fibrosis lung environment and modifies low-molecular-mass lipopolysaccharide

Article Abstract:

A quorum-responsive gene of Pseudomonas aeruginosa, migA, has been found in a study using population transcript analysis expressed in lungs of patients with cystic fibrosis. Experimental results suggest that MigA up-regulation in the CF lung environment is part of the adaptive response which gives P aeruginosa survival advantage.

Canada, Environmental aspects, Endotoxins, Lung diseases, Virulence (Microbiology), Mucus

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Lethality of glnD null mutations in Azotobacter vinelandii is suppressible by prevention of glutamine synthetase adenylylation

Article Abstract:

It has been shown that glnD is an essential gene in Azotobacter vinelandii. Lethality of glnD null mutations in A. vinelandii has been found to be suppressible by prevention of glutamine synthetase adenylylation.

Usage, Reports, Gene mutations, Gene mutation, Enterobacteriaceae, Genetic regulation, Nitrogen, Ligases, Microbiological research, Glutamine

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Enzyme polymorphism in Pseudomas aeruginosa strains recovered from cystic fibrosis patients in France

Article Abstract:

Enzyme polymorphism in Pseudomas aeruginosa is discussed relative to strains recovered from cystic fibrosis patients in France. From 87 patients, 314 strains were recovered and typed by multilocus enzyme eletrophoresis to look at genetic diversity and relatedness and molecular epidemiology of strains from those with chronic pulmonary colonization. No relationships were found between clinical outcome and persistence of stable isolates, emergence of transient superinfecting variants, presence of multiple electrophoretic types (ETs), or ET shift in monitoring. Little genetic diversity was found at 18 loci.

France, Enzymes, Electrophoresis, Genetic polymorphisms, Variation (Biology), Opportunistic infections

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