p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho

Article Abstract:

The roles for both p120-catenin (p120) and p190RhoGAP (p190) in co-coordinating intracellular crosstalk and cadherin-mediated cell-cell adhesion function are described. Receptor-induced Rac activity causes translocation of p190RhoGAP to adherens junctions (AJs) where it couples to the cadherin complex via interaction with p120 and AJ formation is dependent on this p120-p190RhoGAP interaction and fails altogether if either of these proteins are compromised.

Cellular signal transduction, Cell adhesion, Antibiosis, Report

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Canonical notch signaling functions as a commitment switch in the epidermal lineage

Article Abstract:

In vivo molecular and functional evidence is provided to show that in addition to acting as a regulator of epidermal differentiation, Notch also operates at the commitment step to govern the balance between proliferative basal progenitors and terminally differentiating suprabasal progeny. Notch exerts its effects at the basal-suprabasal juncture to specify spinous layers and repress basal epidermal genes by a canonical mechanism dependent on RBP-J.

Cell differentiation, Genetic research

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p120-catenin mediates inflammatory responses in the skin

Article Abstract:

The exhibition of reduced intercellular adherens junction (AJ) components by p120 null neonatal epidermis without overt disruption in barrier function or intercellular adhesion is discussed. NFkB activation and immune homeostasis in part is affected by p120 through regulation of Rho GTPases.

New York, Analysis, Usage, Physiological aspects, Eukaryotes, Homeostasis, Immunoblotting

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