Are ion-exchange processes central to understanding drug-resistance phenomena?

Article Abstract:

Recent scientific data show that alterations in transmembrane ion transport are involved in the multidrug resistance of tumor cells, bacteria and malarial parasites. There is also scientific evidence proving the participation of nonspecific drug pumps in conferring drug resistance in these species. These findings confirm the predictions of an 'indirect' drug-partitioning model which suggests that altered drug accumulation in resistant cells and microorganisms result from changes in pH gradients, electric membrane potential and other biophysical parameters.

Physiological aspects, Drug resistance in microorganisms, Microbial drug resistance, Cancer cells, Malaria, Plasmodium falciparum, Ion exchange

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New year heralds 'open' internal market

Article Abstract:

European Community (EC) member nations on Jan 1, 1993, celebrated the symbolic start of the EC's open internal market. The primary objective of the open market is to permit the unrestricted movement of people, products, capital and information within the EC.

Europe, Economic aspects, European Union, Rituals, Rites and ceremonies, European Community

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Women at risk

Article Abstract:

About one in 200 women have an inherited susceptibility to breast cancer because of a gene called BRCA1. Research has not found a way to prevent breast cancer, so early detection is stressed for high-risk women.

Risk factors, Breast cancer

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