Caged phosphopeptides reveal a temporal role for 14-3-3 in G1 arrest and S-phase checkpoint function

Article Abstract:

Using classical genetics it is difficult to study modular phosphopeptide-binding domains within a family of proteins that were functionally redundant when other members of the family compensate for the product of the knocked-out gene. A chemical genetic approach is described that overcomes the limitation by using UV-activatable caged phospetides.

Methods, Biochemical genetics, Binding proteins

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An anti-infective peptide that selectively modulates the innate immune response

Article Abstract:

The immunomodulating activity of innate defense-regulator peptides (IDR-1) is due to mitogen-activated protein kinase and signaling pathways to increase the levels of monocyte chemokines. It prevents the depletion of monocytes and macrophages in the cells preventing further damage.

Natural immunity, Clinical report

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