Cell-specific targeting of nanoparticles by multivalent attachment of small molecules

Article Abstract:

A study investigates whether multivalent attachment of small molecules can increase specific binding affinity and reveal new biological properties of nanomaterials that can be used in biomedical applications. A model nanoparticle library is screened against different cell lines and states and nanomaterials that discriminate among distinct cell types, or among different physiological states of a given cell type are identified.

Nanotechnology, Phenotype, Phenotypes, Cell research, Cytological research

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Looking and listening to light: The evolution of whole-body photonic imaging

Article Abstract:

The fluorescence and bioluminescence macroscopy in whole animals is carried out using photonic imaging. This method uses tomographic principles to noninvasively image optical contrast at depths of several millimeters to centimeters with high sensitivity and sub-millimeter to millimeter resolution.

Usage, Optical tomography, Animal biochemistry

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A clearer vision for in vivo imaging

Article Abstract:

Diagnostic imaging technologies could benefit from the substitution of small peptides for bulky monoclonal antibodies. The article also refers to "Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands" this issue (p. 327-331).

Medical Instruments and Supplies, In-Vitro Diagnostic Substance Manufacturing, Diagnostic substances, Laboratory Apparatus and Furniture Manufacturing, Clinical Lab Equipment, Monoclonal Antibodies for Imaging, Monoclonal antibodies, Diagnostic imaging, Biomedical laboratory equipment

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