Computational design and experimental validation of oligonucleotide-sensing allosteric ribozymes

Article Abstract:

A study describes a computational strategy for designing new allosteric ribozyme constructs that exhibit robust allosteric activation upon the addition of specific oligonucleotides. The utility of the method is demonstrated by the creation and testing of four universal types of molecular switches possessing AND, OR, YES, and NOT Boolean logic functions, which allows ligand specificity to be changed without altering the catalytic core of the ribozyme.

Catalytic RNA, Allosteric enzymes

---

Prospects for plant-derived antibacterials

Article Abstract:

Plants have their own defense mechanism in combating pathogen infections and this system rivals that of mammalian immune system. Certain chemicals or genome sequences in plants help them fight against infections and researchers are presently paying attention on this ability of plant phytochemicals by combining synergistically to produce new antibacterial treatments.

Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Bacteriostats, Usage, Antibacterial agents, Phytochemicals, Plant defenses, Plant defences

---

Similar abstracts:

• Abstracts: Dividend valuation, trading and transactions costs: the 1997 partial abolition of dividend tax credit repayments
• Abstracts: Recombinant expression of selectivity sulfated proteins in Escherichia coli. The site-specific incorporation of p-iodo-L-phenylalanine into proteins for structure determination
• Abstracts: Molecular engineering approaches to peptide, polyketide and other antibiotics. High-throughput generation of small antibacterial peptides with improved activity

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.