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Directed evolution of thymidine kinase for AZT phosphorylation using DNA family shuffling

Article Abstract:

Researchers from Maxygen Inc., Affymetrix Inc. and the Swiss Federal Institute of Technology developed a new technique of recombining the thymidine kinase genes of two types of herpes simplex virus using DNA family shuffling.

Author: Crameri, Andreas, Stemmer, Willem P.C., Christians, Fred C., Folkers, Gerd, Scapozza, Leonardo
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 1999
Product information, Biological Product (except Diagnostic) Manufacturing, Drugs, Recombinant DNA Products, Brief Article, Recombinant DNA, Affymetrix Inc., AFFX, Maxygen Inc.

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DNA shuffling of subgenomic sequences of subtilisin

Article Abstract:

Researchers from Maxygen, CA, and Novo Nordisk, Denmark screened a DNA family shuffling or molecular breeding of protease genes such as subtilisins from the Bacillus bacteria for various enzymatic properties.

Author: Borchert, Torben V., Welch, Mark, Stemmer, Willem P.C., Minshull, Jeremy, Ness, Jon E., Giver, Lori, Bueno, Manuel, Cherry, Joel R.
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 1999
R&D NEC, Research, Novo Nordisk A/S, Maxygen

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Increasing galactose consumption by Saccharomyces cerevisiae through metabolic engineering of the GAL gene regulatory network

Article Abstract:

Researchers in Denmark and the U.S. have devised a means for genetically altering Saccharomyces cerevisiae to more effectively turn galactose into ethanol.

Author: Johnston, Mark, Nielsen, Jens, Ostergaard, Simon, Olsson, Lisbeth
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2000
Manufacturing processes, Industrial organic chemicals, not elsewhere classified, Ethanol, Ethyl Alcohol Manufacturing

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Subjects list: United States, Denmark, Genetic engineering
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