Early-stage exits: Sometimes less is more

Article Abstract:

Venture capitalist David Mack's first investment, Angiosyn, was created around a single drug, an angiostatic developed by the scientific founders of 'The Scripps Research Institute' in La Jolla. Pfizer acquired the La Jolla, California-based Angiosyn, for $527 million and a cut of royalties on the company's only drug, which was believed to be one of the greatest deals for David Mack.

United States, Venture capitalists (Persons), Mack, David

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Pfizer dumps Exubera

Article Abstract:

New York-based Pfizer decided to abandon, Exubera, the inhaled powdered recombinant human insulin after eleven years of development and one full year of sales. The partner and product originator, San Carlos-based Nektar Therapeutics, however, received a one-time compensation of $135 million and also all the rights to the products so that it can search for a new partner.

Product standards, safety, & recalls, Product defects and recalls, Exubera (Medication)

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Clinical setbacks for toll-like receptor 9 agonists in cancer

Article Abstract:

A clinical program developed by Pfizer for non-small cell lung cancer for PF-3512676, a CpG oligodeoxynucleotide (ODN) drug that activated toll-like receptor 9 (TLR9) of the immune system, due to the drug's limited efficacy. This move has proved to be a setback for TLR drug development as investors are backing out.

Product development, Science & research, Care and treatment, Research, Genetic aspects, Lung cancer, Non-small cell, Non-small cell lung cancer, Oligodeoxynucleotides, Brief article

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