Engineering novel binding proteins from nonimmunoglobulin domains

Article Abstract:

The term 'scaffold' is used to describe a protein framework that could carry altered amino acids or sequence insertions that confer on protein variants different functions, usually for binding specific targets. The motivation to create alternative binding molecules derives from a desire to enable new applications where antibodies show some limitations.

Amino acids, Immunoglobulin genes, Binding proteins

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Design of multivalent complexes using the barnase-barstar module

Article Abstract:

The construction, production and purification of defined dimeric and trimeric complexes are described. A multimerization system based on the very tight interaction between barnase and barstar is described.

Ribonuclease, Dimer acids

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Stable one-step technetium-99m labeling of His-tagged recombinant proteins with a novel Tc(I)-carbonyl complex

Article Abstract:

Researchers from Switzerland and Germany developed a technetium labeling technology involving a novel reagent technetium-carbonyl compound with a His-tagged recombinant protein for use in cancer diagnosis.

Germany, Research and Development in the Physical, Engineering, and Life Sciences, Switzerland, Research and Testing Services, All Other Miscellaneous Chemical Product and Preparation Manufacturing, Chemical preparations, not elsewhere classified, Cancer & Cell R&D, Radioactive Research Chemicals, Cancer research, Specialty chemicals

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