Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging

Article Abstract:

Functional photoacoustic microscopy (fPAM), which provides multiwavelength imaging of optical absorption and permits high spatial resolution, beyond this depth limit with a ratio of maximum imaging depth to depth resolution, greater than 100 is reported. fPAM is demonstrated with in vivo imaging of angiogenesis, melanoma, hemoglobin oxygen saturation of single vessels in animals and total hemoglobin concentration in humans.

Usage, Microscopy, Medical, Medical microscopy

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Brief communications: Reporter proteins for in vivo fluorescence without oxygen

Article Abstract:

The genetically coded fluorescent protein (GFP) probes of vital importance in the in vivo and in vitro imaging of cells and tissues have limited applications due to requirement of oxygen for the synthesis of their chromophores. The process of building up of an oxygen -independent, flavin mononucleotide-based fluorescent protein from blue-green bacteria is discussed in the article.

Medical examination, Fluorescence, Protein research, Biological specimens, Clinical report

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Invention and commercialization in optical bioimaging

Article Abstract:

This article discusses the development of novel imaging applications, based on optical imaging, in biological contexts such as clinical pathology. The author addresses the need for innovation in bioimaging in terms of developing intensity-based, coherence-domain, hyperspectral and photon diffusion techniques.

Analysis, Innovations, Diagnosis, Noninvasive, Noninvasive diagnosis, Images, Optical, Optical images

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