An essential role for Akt1 in dendritic cell function and tumor immunotherapy

Article Abstract:

Akt1 has regulated dendritic cell (DC) survival in innate (LPS-driven) and adaptive (CD40-driven) immune responses by modulating Bcl-2, but not Bcl-(X.sub.L), levels. Atk1 is found to be a critical regulator of DC lifespan and its manipulation in DCs has improved the clinical efficacy of DC-based tumor vaccines, thereby enhancing tumor-specific T-cell responses and eradication of pre-established solid tumors in mice.

T cells, Immune response

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Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunity

Article Abstract:

The silencing suppressor of cytokine signaling (SOCS1), which enhances antigen presentation by dendritic cells (DCs) and antigen-specific anti-tumor immunity, is studied. The findings of the study indicate that the SOCS1 represents an inhibitory mechanism qualitatively and quantitatively controlling antigen presentation by DCs, thus improving the antigen-specific anti-tumor immunity.

Cytokines, Antigens

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A new lease on life for dendritic cell vaccines?

Article Abstract:

A new strategy for improving cancer vaccines based on insights into the regulation of dendritic-cell life span is described. A truncated variant of Akt1 in dendritic cells increases the cell's longevity, advances their maturation and increases the efficacy of dendritic-cell vaccination in murine tumor models.

Care and treatment, Cancer patients, Cancer vaccines

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