Lentiviral vectors ready for prime-time

Article Abstract:

The first clinical trials using lentiviral vector has shown efficient and safe gene delivery to the patients' T cells with good persistence in vivo and also to treat a large number of disorders. Lentiviral vectors are the main elements in advancing gene therapy to expand the conditions and might respond, beyond the primary immune deficiencies that have constituted the sole success to date using gamma-retroviral vectors.

Genetic aspects, Gene therapy, Genetic markers

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Bioinformatics prediction of HIV coreceptor usage

Article Abstract:

A comprehensive summary of the study of viral coreceptor usage is presented with emphasis on the utility and capability of bioinformatics techniques.

Physiological aspects, Cell receptors, Computational biology

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Continuous high-titer HIV-1 vector production

Article Abstract:

HIV-1 vector production is mapped and analyzed.

United Kingdom, Case studies, Vector-borne diseases

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