Gaining confidence in high-throughput protein interaction networks

Article Abstract:

A quantitative method to evaluate proteomics is developed and a logistic regression approach that uses statistical and topological descriptors to predict the biological relevance of protein-protein interactions obtained from high-throughput screens for yeast is presented. The analysis presented helps in analyzing the growing amount of genomic and proteomics data in model organisms and humans.

Genetic research

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Closing the circle of osmoregulation

Article Abstract:

A mathematical model integrates the major components in the response to hyperosmotic shock in yeast, from the osmosensor at the membrane, to signal transduction, to gene regulation of metabolism. A description of the feedback effect of internal glycerol levels on osmotic pressure and cellular volume is included.

United States, All Other Basic Organic Chemical Manufacturing, CHEMICALS AND ALLIED PRODUCTS, Glycerine, Water-electrolyte balance (Physiology), Fluid-electrolyte balance, Osmoregulation, Glycerol, Structure, Glycerin

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Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

Article Abstract:

A new chemical proteomic approach for studying the mechanisms of the action of clinical ABL kinase inhibitors is discussed. The method is found to be extremely useful for drug discovery.

Phosphotransferases

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