Integrative model of the response of yeast to osmotic shock

Article Abstract:

A mathematical description of the cellular response of yeast to hyperosmotic shock is presented in the study. The model integrates a biochemical reaction network comprising receptor stimulation, mitogen-activated protein kinase cascade dynamics, activation of gene expression and adaptation of cellular metabolism with a thermodynamic description of volume regulation and osmotic pressure.

United States, Analysis, Water-electrolyte balance (Physiology), Fluid-electrolyte balance, Osmotic pressure, Osmoregulation

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Principles of transcriptional control in the metabolic network of Saccharomyces cerevisiae

Article Abstract:

A study was conducted to analyze how the coordinated expression of enzymes shapes the metabolic network of Saccharomyces cerevisiae by integrating large-scale expression data with the structural description of the metabolic network. The study revealed that recurrent pattern could represent design principles of metabolic gene regulation.

Genetic aspects, Genetic regulation, Genetic research

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High-resolution genome-wide mapping of histone modifications

Article Abstract:

A combination of sage and chromatin immunoprecipitation (ChIP) protocol is applied to determine the distribution of hyperacetylated histones H3 and H4 in the saccharomyces cerevisiae genome. Findings indicate that GMAT should find valuable applications in mapping target sites of chromatin-modifying enzymes.

Chromatin, Serial analysis of gene expression

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