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Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy

Article Abstract:

The delivery and subsequent migration of cells to regional lymph nodes in dendritic cell therapy is essential for effective stimulation of the immune system. A study demonstrates that in vivo magnetic resonance tracking of magnetically labeled cells is feasible in human melanoma patients for detecting very low numbers of dendritic cells in conjunction with detailed anatomical information.

Author: Adema, Gosse J., Figdor, Carl G., Scheenen, Tom W.J., Bulte, Jeff W.M., de Vries, I. Jolana M., Lesterhuis, W. Joost, Barentsz, Jelle O., Verdijk, Pauline, van Krieken, J. Han, Boerman, Otto C., Oyen, Wim J.G., Bonenkamp,Johannes J., Boezeman, Jan B., Punt, Cornelis J.A., Heerschap; Arend
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2005
Care and treatment, Melanoma, Angiography, Dendritic cells

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Hot spot MRI emerges from the background

Article Abstract:

An alternative approach to magnetic resonance imaging (MRI) of fluorine-labeled cells allows specific detection of cells in vivo without endogenous background signal. The method uses perfluoropolyether nanoparticles, which can be detected directly by (super 19)F imaging, offering several advantages over current strategies based on metal-based contrast agents and (super 1)H imaging.

Author: Bulte, Jeff W.M.
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2005
Observations, Magnetic resonance imaging, DNA-ligand interactions, DNA binding

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Artificial reporter gene providing MRI contrast based on proton exchange

Article Abstract:

A nonmetallic, biodegradable, lysine rich-protein (LRP) reporter, the prototype of a potential family of genetically engineered reporters was designed for expressing artificial proteins with frequency-selective contrast. It was observed that LRP showed no toxic side effects on metabolic mitochondrial rate, cell damage and cell viability, even after multiple culture passages.

Author: Raman, Venu, Bulte, Jeff W.M., Gilad, Assaf A., McMahon, Michael T., Walczak, Piotr, Winnard, Paul T. Jr., van Laarhoven, Hanneke W.M., Skoglund, Cynthia M., van Zijl, Peter C.M.
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2007
Netherlands, Proteins, Atomic properties

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Subjects list: Research, United States, Usage, Gene expression
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