Copper- or phosphine-catalyzed reactions of alkynes with isocyanides. Regioselective synthesis of substituted pyrroles controlled by the catalyst

Article Abstract:

The copper-catalyzed reaction of isocyanides (CNH2EWG) with electron-deficient alkynes (RC(triple bond)CEWG) produced 2,4-di-EWG-subsituted pyrroles selectively, whereas the phosphine-catalyzed reaction of isocyanides with activated alkynes yielded 2,3-di-EWG-substituted pyrroles. It shows that the regioselective synthesis of substituted pyrroles is achieved by merely choosing the catalyst.

Organic compounds, Organic compound synthesis, Cyanides, Pyrrole, Pyrroles

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Kinetic acidity of aliphatic hydrocarbons. Hydrogen isotope exchange with cesium cyclohexylamide in cyclohexlamine

Article Abstract:

Kinetic acidities for methane, ethane, propane, cyclopropane, isobutane, neopentane, tetramethylbutane, norbutane, nortricyclene, and adamantane are reported. This was done with the help of tritiodeprotonation or deuteriodeprotonation in cyclohexylamine that was catalyzed by cesium cyclohexylamide.

Science & research, Industrial Organic Chemicals, Cyclic Crude and Intermediate Manufacturing, Aliphatic Hydrocarbons, Research, Aliphatic compounds, Hydrogen, Hydrogen isotopes, Matter, Kinetic theory of, Kinetic theory

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