Manipulation of human minichromosomes to carry greater than megabase-sized chromosome inserts

Article Abstract:

In order to introduce regions of human chromosomes greater than a megabase into cells of animals, the researchers developed a chromosome-cloning system in which defined regions of human chromosomes can be cloned into a stable human minichromosome vector in homologous recombination-proficient chicken DT40 cells.

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Manipulation of human minichromosomes to carry greater than megabase-sized chromosome inserts

Article Abstract:

In order to introduce human chromosomes greater than a magabase into cells of animals, the researchers developed a chromosome-cloning system in which defined regions of human chromosomes can be cloned into a stable human minichromosome vector in homologous recombination-proficient chicken DT40 cells.

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Production of cattle lacking prion protein

Article Abstract:

The generation and characterization of prion protein Pr[P.sup.C]-deficient cattle produced by sequential gene-targeting system is presented. Brain tissue homogenates are resistant to prion propagation in vitro as assessed by protein misfolding cyclic amplification and Pr[P.sup.C]-deficient cattle might be a useful model for prion research and might provide industrial bovine products free of prion proteins.

United States, Research, Causes of, Genetic aspects, Bovine spongiform encephalopathy, Prions, Prions (Proteins), Prion diseases

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