Nurturing naature:engineering new antibiotics

Article Abstract:

Identifying novel compounds as potential new antibiotics has been enhanced by the ever present problem of antibiotic-resistant pathogens. A new approach for bolstering molecular diversity involves engineering microbial genes to produce enzymes with innovative catalytic properties. "Science" has published two recent papers which describe methods which illustrate structure and function of enzymes responsible for the biosynthesis of two important classes of naturally-occurring antiobiotic agents.

Pharmaceutical Preparation Manufacturing, Systemic Antibiotic Preparations, Antibiotics

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Thinking ahead for effective clinical trials

Article Abstract:

Some critical factors for the progress of clinical trials that should always be considered before proceeding are highlighted. The examples provided illustrate the diversity of challenges that those embarking clinical trials face.

Legal issues & crime, Pharmaceutical preparations, Research, Company legal issue, Pharmaceutical industry, Investigations, Clinical trials

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