The use of single-nucleotide polymorphism maps in pharmacogenomics

Article Abstract:

Variations of single-nucleotide polymorphisms (SNPs) in individual DNA are being revealed and stored into large SNP databases to enable more research on pharmacogenomics.

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A DNA computing readout operation based on structure-specific cleavage

Article Abstract:

The authors describe a structure specific cleavage-based readout strategy for surface-based DNA computing.The readout is simple, accurate and compatible with multi-word DNA computing.

Biochemistry, Research and Development in the Physical, Engineering, and Life Sciences, Illustration

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Polymorphism identification and quantitative detection of genomic DNA by invasive cleavage of oligonucleotide probes

Article Abstract:

Researchers from Third Wave Technologies used flap endonucleases isolated from archaea to demonstrate its cleavage when its oligonucleotides attaches itself to a target DNA strand.

Brief Article, Third Wave Technologies Inc.

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