Putting the rat on the map

Article Abstract:

The interesting fact regarding the availability of the rat genome sequence is that biology of the rat can be better understood as it is the most widely used animal species in physiology studies and in drug discovery and development. They are also the most widely used animals in drug safety studies.

Nucleotide sequence, Base sequence, Genomes, Genetic research, Physiological research

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Systemic tumor targeting and killing by Sindbis viral vectors

Article Abstract:

The successful delivery, infection, and eradication of tumor cells by Sindbis vectors in live mice are monitored. The study revealed that in addition to tumor eradication by vector infection, Sindbis vectors could be powerful tools for systemic detection of tumor metastases.

Genetic aspects, Cancer cells

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An archael endoribonuclease catalyzes cis- and trans-nonspliceosomal splicing in mouse cells

Article Abstract:

The potential of using the strategy for repairing RNA in higher organisms by expressing the enzyme in mouse cells are demonstrated. A new nonspliceosomal splicing system in mouse cells is engineered.

United States, Methods, Catalysis, RNA synthesis

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