Signal sequences directing cotranslational translocation expand the range of proteins amenable to phage display

Article Abstract:

The display levels of a range of proteins using different translocation pathways, by employing different signal sequences are tested, as translocation is an intermediate step in phage assembly. It showed that directing proteins to the cotranslational signal recognition particle (SRP) translocation pathway resulted in much higher display levels than directing them to the conventional post-translational Sec translocation pathway.

United States, Bacteriophages, Translocation (Genetics), Protein research, Translocations (Genetics)

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Parent protection for protein structure analysis

Article Abstract:

The implications in biotechnology industry regarding the patents of three-dimensional structural data and pharmacophores of protein, by three national patent offices across the world are presented. Invention described within vivo or in vitro experimental results revealed that the protein structural information or pharmacophores are as effective as patent strategy.

Drugs, Biotechnology industry, Biotechnology industries, Protein binding

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