Targeting cytokines to inflammation sites

Article Abstract:

Research describes a fusion proein engineered with cytokine action to target sites of inflammation. The fusion protein uses the latency-associated protein of transforming growth factor-beta1, which is fused to interferon-beta at one of the protein terminals. Data indicate that the fusion protein is activated by cerebrospinal fluid or synovial fluid from patients with inflammatory diseases but not by serum samples.

United Kingdom, France, Drug therapy, Drug use, Transforming growth factors, Cytokines, Interferon beta

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Suppression of vascular permeability and inflammation by targeting of the transcription factor c-Jun

Article Abstract:

A demonstration that knockdown of the basic-region leucine zipper protein, c-Jun, by a catalytic DNA molecule, Dz13, suppresses vascular permeability and transendothellal emigration of leukocytes in murine models of vascular permeability, inflammation, acute inflammation and rheumatoid arthritis is presented. Result is found to implicate c-Jun as a useful target for anti-inflammatory therapies.

Care and treatment, Cells, Cell permeability, Protein research

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A genetic approach to inactivating chemokine receptors using a modified viral protein

Article Abstract:

Research describes the construction of the fusion protein, degrakine, which specifically inactivates chemokine receptors by redirecting the HIV-1 protein, Vpu, to degrade CD4 in the endoplasm reticulum through proteasome of the host.

Physiological aspects, CD4 lymphocytes, HIV antigens, Viral proteins, Chemokine receptors

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