Therapeutic targeting of a stem cell niche

Article Abstract:

The hypothesis that targeting the niche might improve stem cell-based therapies was tested using three mouse models that are relevant to clinical uses of hematopoietic stem (HS) cells. The findings revealed that pharmacologic use of parathyroid hormone (PTH) increases the number of HS cells mobilized into the peripheral blood for stem cell harvests, protect stem cells from repeated exposure to cytotoxic chemotherapy and expand stem cells in transplant recipients.

Science & research, Health aspects, Research, Usage, Stem cells, Hematopoietic stem cells, Stem cell transplantation, Hematopoietic stem cell transplantation

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Site-specific gene targeting in mouse embryonic stem cells with intact bacterial artificial chromosomes

Article Abstract:

A study is conducted to develop an efficient method for preparing targeted gene disruptions in embryonic stem cells. The conclusion states that site-specific gene disruption in mice is an important tool for the analysis of gene function in vivo.

Case studies, Artificial chromosomes, Gene targeting

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Cloning by numbers

Article Abstract:

A new technique in mouse cloning shows that the simple procedure of embryo aggregation can improve cloning outcomes. Cloned embryos are associated with low rates of pregnancy and birth, and high proportion of abnormal newborns.

Patient outcomes, Causes of, Cloning, High risk pregnancy

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