Toll-like receptor therapies compete to reduce side effects

Article Abstract:

The latest progress in the field of an emerging class of highly specific immunomodulator drugs targeting toll-like receptors (TLR) is discussed. Coley Pharmaceuticals of Wellesley, Massachusetts, and Dynavax Technologies of Berkeley, California, are the only two companies that are in phase 3 clinical trials to bring their TLR-based products on the market by optimizing drug efficacy and reducing side-effects.

Pharmaceutical preparations, Usage, Pharmaceutical industry, Immunosuppressive agents, Coley Pharmaceutical Group Inc., Dynavax Technologies Corp.

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Belated approval of first recombinant protein from animal

Article Abstract:

The London-based European Medicines Agency (EMEA) approved ATryn, GTC Biotherapeutics drug, the first drug to be produced in an animal bioreactor, four months after its initial rejection citing dosages inconsistencies. The EMEA has approved the drug on the condition that GTC monitor clinical uses for antibody reactions

Government regulation, Drugs, Biological products industry, Licensing, certification and accreditation, Antithrombins, European Agency for the Evaluation of Medicinal Products, GTC Biotherapeutics Inc.

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Clinical setbacks for toll-like receptor 9 agonists in cancer

Article Abstract:

Pfizer has dropped a clinical program in non-small cell lung cancer for PF-3512676, a CpG (ODN) drug that activated toll-like receptor 9 (TLR9) of the immune system, due to the drug's limited efficacy. This move has proved to be a setback for TLR drug development as investors are backing out.

Science & research, Research, Observations, Lung cancer, Oligodeoxynucleotides

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