DNA detection method based on the two-dimensional aggregation and selective desorption of nanoparticle probes

Article Abstract:

A label-free two-dimensional colorimetric DNA sensor, which is based on the two-dimensional aggregation of oligonucleotide-modified gold nanoparticle probes induced by the molecular hybridization of single-stranded oligonucleotide probes and their complementary single-stranded DNA targets, is reported. The aggregation is detected by a new method based on the selective desorption of nonaggregated nanoparticles that is highly specific and allows the quantification of the DNA targets.

Usage, Biosensors, Hybridization

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Hybridization detection of DNA by measuring organic small molecule amplified resonance light scattering signals

Article Abstract:

Quinone-imine dyes are investigated based on the measurements of enhanced resonance light scattering (RLS) and TEM. A new technique is also proposed to detect the hybridization and mismatch of DNA labeling neither the target nor the probe DNA.

Nucleic acid hybridization, Light scattering

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