Interpreting DNA vibrational circular dichroism spectra using a coupling model from two-dimensional infrared spectroscopy

Article Abstract:

The experimentally derived coupling model is used to simulate and interpret the absorption and vibrational circular dichroism (VCD) spectra of several model double-stranded nucleic acids in the region of the nucleobase carbonyl stretches. It was found that VCD and absorption spectra for all the oligomers, poly(dG)-poly(dC), poly(dG-dC)-and dGGCC can be simulated within the uncertainties of the coupling model.

Nucleic Acids, Infrared spectroscopy, Circular dichroism

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Inter and intrastrand vibrational coupling in DNA studied with heterodyned 2D-IR spectroscopy

Article Abstract:

Heterodyned 2D-IR, frequency resolved photon echo, and pump - probe spectroscopies were collected to study the couplings and anharmonicities of cytidine and guanosine bases in DNA. Cross-peaks between the G and C carbonyl bands that are interpreted as interstrand coupling across the two oligomers is observed, and strong intrastrand coupling between stacked G carbonyls is also presented.

Methods, Properties, Radioactivation analysis, Activation analysis, Guanosine, Cytidine diphosphate choline

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DNA vibrational coupling revealed with two-dimensional infrared spectroscopy: Insight into why vibrational spectroscopy is sensitive to DNA structure

Article Abstract:

Two-dimensional infrared (2D IR) spectroscopy is applied to study the carbonyl vibrational modes of guanine and cytosine bases in A- and B-form DNA. The results have shown that the coupling is very strong for both hydrogen-bonded and stacked base geometries, creating vibrational modes that extend both across the base pairs and along the lengths of the helices.

Spectra, Vibrational spectra, Structure

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