Tilt: Major factor in sterols' ordering capability in membranes

Article Abstract:

Extensive atomistic simulations are used to show that the single measurable parameter, the sterol tilt, can be used to determine a sterol's capability to induce order and to modify membrane properties. The smaller the tilt, the stronger was the ordering ability of a given sterol. This method differentiates the many sterols and therefore facilitates studies to find sterol molecules comparable to cholesterol in promoting the formation of highly ordered lipid rafts.

Analysis, Electric properties, Blood lipids, Sterols

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Relating the organization of the molecular tilt azimuth to lateral-force images in monolayers transferred to solid substrates

Article Abstract:

A study was conducted to analyze the molecular tilt azimuth in domains of a condensed phase in monolayers of glcyerol esters at the air/water interface. The molecular tilt azimuth supported a regular star texture. In addition, there were regular patterns in images of monolayers on mica. Experimental results indicated that domains transferred to mica do not support the structure they had on the water surface.

Research, Molecular dynamics, Monomolecular films, Esters, Glycerol

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Replacing the cholesterol hydroxyl group with the ketone group facilitates sterol flip-flop and promotes membrane fluidity

Article Abstract:

The effects of substitution of hydroxyl group with the ketone group in cholesterol to produce ketosterone are investigated. The unstable positioning of the ketosterone at the membrane-water interface gives rise to flip-flop transitions, which decrease the polar interactions at the interface allowing ketosterone to penetrate from the hydrocarbon region of the membrane.

Cholesterol, Hydrocarbons, Ketones, Chemical properties

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