A critical appraisal of the evolution of N-nitrosoureas as anticancer drugs

Article Abstract:

The most recent generation, Fourth, of N-nitrosourea analogs with anticancer activities include amino acid and carbohydrate analogs with aminoxyl (nitroxyl) moieties, and conjugates such as steroid-amino acids. The First Generation of N-nitrosourea analogs with anticancer activities consist of heterocyclic, aromatic, alicyclic and lipophilic aliphatic analogs. The Second Generation comprises hydroxyalicyclic and hydroxyalkyl analogs, while the Third Generation comprises analogs containing carrier-groups such as nucleotides and peptides. The anticancer activity of N-nitrosourea drugs will be affected by carcinogenicity, toxicology, pharmacology and metabolism.

History, Antineoplastic agents, Peptides, Nucleotides, Amino acids

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Electron transfer at semiconductor electrode-liquid electrolyte interfaces

Article Abstract:

The photoelectrochemical process, semiconductor-electrolyte interface (SEI), provides an improved method of measuring electron-transfer (ET) reactions. SEI processes exhibit variations depending on the type of semiconductor electrode and redox electrolyte employed. The electrode materialsused are composed of single crystals, polycrystalline thin films, macroscopic titanium dioxide and quantized-layers, while electrolyte redox solutions involve polymer films, diffusive, adsorbed and immobilized systems. Furthermore, monitoring the duration of photogenerated reactants determines interfacial ET reaction rates.

Methods, Usage, Semiconductors, Electrochemistry, Charge transfer, Electrodes, Photochemistry

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